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Description
Maria A. Nieves-Colón, PhD, and Andrés Moreno-Estrada, PhD, will discuss the results of a study investigating genetic factors associated with preeclampsia amongst altitude resident families in the Andean Highlands.
Overview of Presentation
- Preeclampsia is a hypertensive complication of pregnancy that is a major cause of maternal-infant morbidity and mortality worldwide.
- Risk for developing preeclampsia increases amongst high altitude resident populations.
- This study investigated genetic factors underlying preeclampsia among a sample of case and control Andean Highlander family trios.
- Our analyses found associations between preeclampsia and common genetic variants within clotting factor genes, suggesting that irregular coagulation may play a role in preeclampsia risk at high altitudes.
- These variants are candidates for future replication and functional validation in other Latin American or high-altitude resident cohorts
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