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Description
Dr. Genevieve Wojcik will discuss the role of social determinants of health in genetic epidemiology, specifically the need for careful consideration from study design to interpretation. She will present two vignettes to illustrate: (1) a study of enteric infections in Bangladeshi infants, which required homogeneity of SDOH to better isolate genetic effects, and (2) the role of heterogeneity within Hispanic/Latino populations and how this can influence our estimates of genetic risk. Together, these vignettes will show how both homogeneity and heterogeneity in SDOH can influence genetic studies of human health.
Overview of Presentation
- Human genetics are part of a complex system contributing to health.
- This system includes both individual-level and structural contributors.
- These structural influences can introduce heterogeneity both within and between populations.
- Genetic studies must consider societal contexts in order to appropriately account for these contributions in analyses and ensure appropriate interpretations of results.
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