GWAS

The American Society of Human Genetics (ASHG) today published a new Guidance on the challenges in the development and application of polygenic scores (PGS) in human genetic research. Appearing in today’s issue of the American Journal of Human Genetics (AJHG), this new resource was developed by a writing group led by members of the ASHG... Read More

Posted By: Sarah Ratzel, PhD, Science Editor, AJHG Each month, the editors of The American Journal of Human Genetics interview an author of a recently published paper. This month, we check in with Jason Torres to discuss his paper, “A Multi-omic Integrative Scheme Characterizes Tissues of Action at Loci Associated with Type 2 Diabetes”. AJHG:... Read More

Published: Monday, October 26, 2020, 12:00 p.m. U.S. Eastern Time Media Contact: Kara Flynn, 202.257.8424, press@ashg.org ROCKVILLE, MD — Researchers announce the first robust evidence for the role of the major histocompatibility complex gene HLA-B in penicillin allergy. To identify genetic risk factors for penicillin allergy, the international team of researchers harnessed self-reported data and the electronic... Read More

Posted By: Sara Cullinan, PhD, Deputy Editor, AJHG Each month, the editors of The American Journal of Human Genetics interview an author of a recently published paper. This month we check in with Mark McCarthy (@markmccarthyoxf) to discuss his paper “A Multi-tissue Transcriptome Analysis of Human Metabolites Guides Interpretability of Associations Based on Multi-SNP Models... Read More

Trainee Author: Arne De Roeck, M.Sc PhD Student, Neurodegenerative Brain Diseases Group VIB-UAntwerp Center for Molecular Neurology (Photo courtesy De Roeck) De Roeck A, et al. An intronic VNTR affects splicing of ABCA7 and increases risk of Alzheimer’s disease. Acta Neuropathologica. 2018 Mar 27;135(6) This paper underscores the importance of considering non-coding variation while searching... Read More