Trainee Paper Spotlight

Trainee Author: Taylor Mighell Graduate Student Oregon Health and Science University, Portland, Oregon (Photo courtesy Mighell) Mighell, T.L., Evans-Dutson, S. and O’Roak, B.J. (2018) A Saturation Mutagenesis Approach to Understanding PTEN Lipid Phosphatase Activity and Genotype-Phenotype Relationships. The American Journal of Human Genetics 102, 943–955. Mighell et al (2018) present a methodology and framework for... Read More

Trainee Author: Bárbara Domingues Bitarello, PhD Postdoctoral Researcher, Department of Genetics Perelman School of Medicine, University of Pennsylvania (Photo courtesy Bitarello) Bitarello BD, et al. Signatures of long-term balancing selection in human genomes. Genome Biology and Evolution. 2018 Mar 1;10(3) In this month’s Trainee Paper Spotlight, Bitarello et al. define a simple yet powerful new... Read More

Trainee Author: Arne De Roeck, M.Sc PhD Student, Neurodegenerative Brain Diseases Group VIB-UAntwerp Center for Molecular Neurology (Photo courtesy De Roeck) De Roeck A, et al. An intronic VNTR affects splicing of ABCA7 and increases risk of Alzheimer’s disease. Acta Neuropathologica. 2018 Mar 27;135(6) This paper underscores the importance of considering non-coding variation while searching... Read More

Trainee Author: Yong Lei, PhD Postdoctoral Associate Fellow, Stem Cells & Regenerative Medicine Centre, Baylor College of Medicine (BCM), Houston, Texas (Photo courtesy Lei) Lei, Y. et al. Targeted DNA methylation in vivo using an engineered dCas9-MQ1 fusion protein. Nat. Commun. 8, 16026 doi: 10.1038/ncomms16026 (2017). Yong Lei and colleagues report a new engineered tool... Read More

Trainee Author: Saumya Jamuar, MBBS MRCPCH Attending, Genetics Service, Department of Paediatrics, KK Women’s and Children’s Hospital, Singapore Asst Professor, Paediatrics ACP, Duke-NUS Medical School, Singapore Clinical Director, Institute of Precision Medicine (PRISM), Duke-NUS Medical School, Singapore PI and Clinical Lead, Singapore Undiagnosed Disease Programme, Singapore Co-founder and co-Chief Scientific Officer, Global Gene Corp (Photo... Read More