Posted By: HGG Advances HGGA: What motivated you to start working on this project? SG: I’ve been very interested in understanding differences in gene regulation across human populations and how genetic ancestry shapes gene expression. However, when I started thinking seriously about studying these questions at the cell-type resolution, I realized that multi-ancestry single-cell datasets... Read More
Posted By: HGG Advances HGGA: What motivated you to start working on this project? Authors: Heart failure is common and deadly, but its genetics are hard to nail down because it’s highly polygenic, and many genome-wide association study signals haven’t been translated into actionable biology or treatment ideas. We were motivated by the strong genetic overlap between... Read More
For Immediate Release: Tuesday, October 14, 2025, 11:00 a.m. U.S. Eastern Time Media Contact: Evelyn Mantegani, 202-725-2730, [email protected] Each year, editors of The American Journal of Human Genetics (AJHG) and Human Genetics and Genomics Advances (HGG Advances) recognize trainees and early career investigators for outstanding scientific contributions to the field of human genetics and genomics. We’re... Read More
Posted By: HGG Advances HGGA: What motivated you to start working on this project? Most genomic research has focused on individuals of European ancestry and has commonly used imputation panels that contain more European haplotypes, leading to poorer accuracy in other ancestries. In addition, standard panels are largely disease-agnostic, whereas ours is built from Alzheimer’s... Read More
Posted By: HGG Advances HGGA: What motivated you to start working on this project? OP: Despite significant advances in our understanding of the genetic basis of complex traits and diseases — and the potential of polygenic scores (PGS) to guide personalized medicine — these tools are still only beginning to enter clinical use. A major... Read More